- Title
- Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: is gastroparesis a factor?
- Creator
- Tavakkoli, Anna; Sayed, Bisma A.; Talley, Nicholas J.; Moshiree, Baharak
- Relation
- World Journal of Gastroenterology Vol. 19, Issue 37, p. 6193-6198
- Publisher Link
- http://dx.doi.org/10.3748/wjg.v19.i37.6193
- Publisher
- Baishideng Publishing
- Resource Type
- journal article
- Date
- 2013
- Description
- Aim: To determine whether an increased number and duration of non-acid reflux events as measured using the multichannel intraluminal impedance pH (MII-pH) is linked to gastroparesis (GP). Methods: A case control study was conducted in which 42 patients undergoing clinical evaluation for continued symptoms of gastroesophageal reflux disease (both typical and atypical symptoms) despite acid suppression therapy. MII-pH technology was used over 24 h to detect reflux episodes and record patients’ symptoms. Parameters evaluated in patients with documented GP and controls without GP by scintigraphy included total, upright, and supine number of acid and non-acid reflux episodes (pH < 4 and pH > 4, respectively), the duration of acid and non-acid reflux in a 24-h period, and the number of reflux episodes lasting longer than 5 min. Results: No statistical difference was seen between the patients with GP and controls with respect to the total number or duration of acid reflux events, total number and duration of non-acid reflux events or the duration of longest reflux episodes. The number of non-acid reflux episodes with a pH > 7 was higher in subjects with GP than in controls. In addition, acid reflux episodes were more prolonged (lasting longer than 5 min) in the GP patients than in controls; however, these values did not reach statistical significance. Thirty-five patients had recorded symptoms during the 24 h study and of the 35 subjects, only 9% (n = 3) had a positive symptom association probability (SAP) for acid/non-acid reflux and 91% had a negative SAP. Conclusion: The evaluation of patients with a documented history of GP did not show an association between GP and more frequent episodes of non-acid reflux based on MII-pH testing.
- Subject
- gastroparesis; non-acid gastroesophageal reflux; acid gastroesophageal reflux; multi-channel intraluminal impedance; functional bowel disorder
- Identifier
- http://hdl.handle.net/1959.13/1311559
- Identifier
- uon:22234
- Identifier
- ISSN:1007-9327
- Language
- eng
- Full Text
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